Product Review: DNA sequencers rely on CE
نویسندگان
چکیده
منابع مشابه
Impact of the next generation DNA sequencers.
New generation sequencers have been developed with a strong impact on genomics. These sequencers are based on a principle different from the Sanger method, and can sequence one to several million templates in a single run, albeit read length is relatively small. The current large-scale efforts are: 1) complete genome sequencing of 1,000 individuals, the primary objective of which is identificat...
متن کاملThe sequence of sequencers: The history of sequencing DNA
Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers have applied themselves to the production of techniques and technologies to facilitate this feat, sequencing DNA and RNA molecules. This time-scale has witnessed tremendous changes, moving from sequencing...
متن کاملReconstructing fragmented gel files created by Model 377 DNA Sequencers.
To our knowledge, the most widely used automated DNA sequencers are manufactured by PE Applied Biosystems (Foster City, CA, USA). Our laboratory uses Model 377 Sequencers equipped with the XL upgrade (i.e., collection software Version 2.0 and analysis software Version 3.0). Power transients, network noise, an excessively fragmented hard disk or other such incidents can cause a sequencer to prem...
متن کاملA DNA cycle sequencing reaction that minimizes compressions on automated fluorescent sequencers.
We recently demonstrated that most band compressions (>70%) on DNA sequencing gels result from the presence of a single sequence motif, 5'-YGN1-2AR-3', where Y and R indicate base-pairing pyrimidine and purine residues, respectively. This finding raised the possibility that the use of 7-deaza-dATP instead of dATP in chain termination sequencing reactions would resolve most of the band compressi...
متن کاملOn Rely-Guarantee Reasoning
Many semantic models of rely-guarantee have been proposed in the literature. This paper proposes a new classification of the approaches into two groups based on their treatment of guarantee conditions. To allow a meaningful comparison, it constructs an abstract model for each group in a unified setting. The first model uses a weaker judgement and supports more general rules for atomic commands ...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2001
ISSN: 0003-2700,1520-6882
DOI: 10.1021/ac012461o